Oxysterols and Gastrointestinal Cancers Around the Clock

PARP around the Clock

Cells possess internal ∼24 hr or circadian clocks that synchronize physiological processes with daily cycles of light and nutrient availability. In this issue, Asher et al. (2010) find that PARP-1 (poly(ADP-ribose) polymerase 1) modifies components of the clock machinery in response to feeding, providing a mechanism for how metabolic rhythms coordinate with circadian rhythms.

SRF’ing Around the Clock

Central circadian clock oscillators, located in the suprachiasmatic nucleus (SCN) of the hypothalamus, align peripheral clock systems with geosynchronous time. Gerber et al. (2013) identify actin polymerization and serum response factor (SRF) activation as key steps linking the central master clock to peripheral oscillators.

Myocardial repair around-the-clock.

Spiritual Health in the Patients with Gastrointestinal Cancers and Its Relation with General Health

Introduction: Today, issues related to meaning and spirituality are accepted as essential parts of chronic diseases’ experience as they may seriously affect people's attitude towards their ego, illness and future. The present study was conducted to investigate the spiritual health of the patients with gastrointestinal cancers and its association with general health. Methods: This cross-section...

Selenium and gastrointestinal cancers risk

Material and methods The research material was a total of 110 samples of blood serum from people with cancer, diagnosed and confirmed in one of the organs: colon (67 cases), pancreas (30 cases) or stomach (13 cases) and 110 samples of blood serum derived from healthy individuals representing paired control group. The criteria adopted for pairing included: gender, year of birth (+/3 years), hist...